JRTDD indexed into ROAD

Dear readers,

I want to announce that JRTDD is already into ROAD. It is one more achievment of editorial office. This our 21st indexation. ROAD is Directory of Open Access Scholarly Resources.

ROAD has been developed with the support of the Communication and Inform…ation Sector of UNESCO, it provides a free access to a subset of the ISSN Register. This subset comprises bibliographic records which describe scholarly resources in Open Access identified by an ISSN : journals, monographic series, conference proceedings and academic repositories. ROAD records are enriched by metadata about the coverage of the resources by indexing and abstracting databases, registries and journals indicators. They are downloadable as a MARC XML dump and will be available as RDF triples in 2014.

With respect,

JRTDD Editor-in-chief



JRTDD indexed into ScienceOpen

Respected colleagues,

With great happiness I want to inform you that JRTDD is already indexed into ScienceOpen. After several months of negotiations finally we succeed it. We hope that this indexing will increase the visibility and readership world wide.

What is ScienceOpen?

ScienceOpen is a discovery platform with interactive features for scholars to enhance their research in the open, make an impact, and receive credit for it. We provide context building services for publishers, to bring researchers closer to the content than ever before. Our advanced search and discovery functions, combined with post-publication peer review, recommendation, social sharing, and collection-building features make ScienceOpen the only research platform you’ll ever need.

With respect,

JRTDD Editor-in-chief


Immune, Autonomic, and Endocrine Dysregulation in Autism and Ehlers-Danlos Syndrome/Hypermobility Spectrum Disorders Versus Unaffected Controls

Emily L. Casanova1,
Julia L. Sharp2,
Stephen M. Edelson3,
Desmond P. Kelly1, 4,
Estate M. Sokhadze1,
Manuel F. Casanova1, 4

1Department of Biomedical Sciences, University of South Carolina
School of Medicine Greenville, South Carolina, USA
2Department of Statistics, Colorado State University, Fort Collins, Colorado, USA
3Autism Research Institute (ARI), San Diego, California, USA
4Department of Pediatrics, Greenville Health System Children’s Hospital, Greenville, South Carolina, USA
E-mail: casanove@greenvillemed.sc.edu
Received: 1-October-2019
Revised: 23-October-2019
Accepted: 30-October-2019
Online first: 31-October-2019


Background: A growing body of literature suggests etiological overlap between Ehlers-Danlos syndrome (EDS)/hypermobility spectrum disorders (HSD) and some cases of autism, although this relationship is poorly delineated. In addition, immune, autonomic, and endocrine dysregulation are reported in both conditions and may be relevant to their respective etiologies.

Aims: To study symptom overlap in these two comorbid spectrum conditions.

Methods and Procedures: We surveyed 702 adults aged 25+ years on a variety of EDS/HSD-related health topics, comparing individuals with EDS/HSD, autism, and unaffected controls.

Outcomes and Results: The autism group reported similar though less severe symptomology as the EDS/HSD group, especially in areas of immune/autonomic/endocrine dysregulation, connective tissue abnormalities (i.e., skin, bruising/bleeding), and chronic pain. EDS/HSD mothers with autistic children reported more immune symptoms than EDS/HSD mothers without, suggesting the maternal immune system could play a heritable role in these conditions (p = 0.0119).

Conclusions and Implications: These data suggest that EDS/HSD and autism share aspects of immune/autonomic/endocrine dysregulation, pain, and some tissue fragility, which is typically more severe in the former. This overlap, as well as documented comorbidity, suggests some forms of autism may be hereditary connective tissue disorders (HCTD).

Key words: hereditary connective tissue disorders, immune system, collagen, dysautonomia, mast cell activation disorders

Citation: Casanova, E. L., Sharp, J. L., Edelson, S. M., Kelly, D. P., Sokhadze, E. M., Casanova, M. F. Immune, Autonomic, and Endocrine Dysregulation in Autism and Ehlers-Danlos Syndrome/Hypermobility Spectrum Disorders Versus Unaffected Controls. Journal for ReAttach Therapy and Developmental Diversities. https://doi.org/10.26407/2019jrtdd.1.20

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